This is the solution to Crease puzzle #18. The puzzle gives you a strip of 8 numbers and asks you to fold it 2 times to reach a strip of 5 numbers.
Folding only adds numbers together, so the total never changes. Both strips add up to 41. Your largest target number, 22, must be a stack of several cells added together.
The strip has 8 cells and the target has 5, so the folds together must remove 3 cells. A fold removes as many cells as its shorter side has.
The first fold goes between cell 6 and cell 7, counting cells from the left.